Paulo Dybala, Romelu Lukaku and Stephan El Shaarawy lead the Roma attack under Daniele De Rossi, while Salernitana look to Antonio Candreva and Guillermo Ochoa.
It kicks off at the Stadio Arechi at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Giallorossi had a winning start on De Rossi’s debut after the shock dismissal of Jose Mourinho, beating Verona 2-1.
Gianluca Mancini and Bryan Cristante were both suspended for that match, but return here, though Leandro Paredes sits out a ban instead.
Leonardo Spinazzola, Renato Sanches, Marash Kumbulla, Chris Smalling and Tammy Abraham are still injured, with Evan Ndicka and Sardar Azmoun on international duty.
De Rossi is sticking with the four-man defence, scrapping Mourinho’s 3-5-2 formation.
Salernitana are rock bottom after three consecutive defeats, although they were all extremely tight and often controversial.
President Danilo Iervolino was so furious that he threatened to take legal action against the Lega Serie A and even leave the league entirely.
Some of the issues are their own, though, having fumbled 18 points from leading situations this season.
Boulaye Dia and Lorenzo Pirola are injured, with Federico Fazio not fully fit, while Lassana Coulibaly and Jovane are at the Africa Cup of Nations.
Loum Tchaouna and Candreva support striker Nwankwo Simy.
This is a reunion on the touchline between 2006 World Cup winning teammates De Rossi and Inzaghi.
Salernitana: Ochoa; Pierozzi, Gyomber, Daniliuc, Sambia; Basic, Maggiore, Bradaric; Candreva, Tchaouna; Simy
Roma: Rui Patricio; Karsdorp, Mancini, Llorente, Kristensen; Pellegrini, Cristante, Bove; Dybala, Lukaku, El Shaarawy
Player statistic
| Niccolò Pierozzi |  |
43' | ||
| 45+3' | |
Lorenzo Pellegrini |
| 51' |  |
Paulo Dybala | ||
| 66' |  |
Lorenzo Pellegrini (Assist: Rick Karsdorp) | ||
| Grigoris Kastanos (Assist: Loum Tchaouna) |
|
70' | ||
| 84' | |
Paulo Dybala | ||
| Antonio Candreva | |
87' | ||
| 89' | |
Rui Patrício |
Match statistic
