Napoli are without Kvicha Kvaratskhelia, so Victor Osimhen is flanked by Eljif Elmas and Chucky Lozano against chaotic Salernitana’s Guillermo Ochoa, Boulaye Dia and Krzysztof Piatek in the Derby di Campania.
It kicks off at the Stadio Arechi at 17.00 GMT.
This has been a remarkable week for both clubs in the Campania region, as Napoli went nine points clear at the top of the Serie A table and then crashed out of the Coppa Italia on penalties to 10-man Cremonese.
Salernitana sacked Davide Nicola following the 8-2 defeat to Atalanta, then recalled the coach 48 hours later.
Kvicha Kvaratskhelia is out with flu symptoms and Juan Jesus picked up a knock in the Coppa Italia, so Elmas steps in with Lozano to support Capocannoniere Osimhen.
The hosts are missing Federico Fazio, Pasquale Mazzocchi, Giulio Maggiore, Luigi Sepe, Dylan Bronn and Ivan Radovanovic.
Nicola opts for a change of system to four at the back, with Antonio Candreva supporting Dia and Piatek.
It’s set to be another busy evening for Mexico international goalkeeper Guillermo Ochoa.
Salernitana: Ochoa; Daniliuc, Gyomber, Pirola, Bradaric; Coulibaly, Nicolussi Caviglia, Vilhena; Candreva; Dia, Piatek
Napoli: Meret; Di Lorenzo, Rrahmani, Kim Min-jae, Mario Rui; Anguissa, Lobotka, Zielinski; Lozano, Osimhen, Elmas