Inter must shake off their first defeat of the season and give Davy Klaassen and Alexis Sanchez a chance, while Salernitana can count on Boulaye Dia, but not Antonio Candreva.
It kicks off at the Stadio Arechi at 19.45 UK time (18.45 GMT).
Simone Inzaghi’s men saw their 100 per cent Serie A record evaporate with a shock 2-1 home defeat to Sassuolo in the midweek round.
Davide Frattesi picked up a muscular injury in that game and is out of action along with Juan Cuadrado, Stefano Sensi and Marko Arnautovic.
Squad rotation is still necessary ahead of the Champions League, so Alexis Sanchez steps in for Lautaro Martinez and Klaassen gets his first start in place of Henrikh Mkhitaryan.
Salernitana have struggled badly so far this season and are still without a victory, losing 1-0 midweek to rock bottom Empoli.
Candreva is still out injured and misses the clash with his former club, joining Lassana Coulibaly and Chukwubuikem Ikwuemesi on the treatment table.
However, Dia returns to the starting XI for the first time in a month, supported by Jovane Cabral and Grigoris Kastanos, while Guillermo Ochoa is always tough to get past in goal.
Salernitana: Ochoa; Daniliuc, Gyomber, Lovato; Bohinen, Legowski, Martegani, Kastanos, Bradaric; Cabral, Dia
Inter: Sommer; Pavard, De Vrij, Acerbi; Dumfries, Klaassen, Calhanoglu, Barella, Carlos Augusto; Alexis Sanchez, Thuram
Player statistic
| 25' |  |
Hakan Calhanoglu |
| Jovane | |
60' | ||
| 62' |  |
Lautaro Martínez (Assist: Marcus Thuram) | ||
| Norbert Gyomber | |
69' | ||
| 77' | |
Lautaro Martínez (Assist: Nicolò Barella) | ||
| 85' |  |
Lautaro Martínez | ||
| 89' | |
Lautaro Martínez (Assist: Carlos Augusto) |
Match statistic
