Roma have Lorenzo Pellegrini back in the starting XI with Romelu Lukaku and Paulo Dybala against an Udinese side that is difficult to break down.
It kicks off at the Stadio Olimpico at 17.00 GMT.
You can follow all the build-up and action as it happens from today’s Serie A games on the LIVEBLOG.
The Giallorossi had been surging up the standings with four wins out of five, but stalled before the break for international duty with a goalless Derby della Capitale draw.
Nonetheless, with Fiorentina and Atalanta already losing this weekend, a win here would leapfrog Jose Mourinho’s men into fifth place.
The injury list is starting to calm down a little, as Pellegrini is back after a series of muscular issues, but Renato Sanches, Chris Smalling, Tammy Abraham and Marash Kumbulla are still out.
Udinese dragged themselves out of the relegation zone with a shock victory away to Milan and then held Atalanta to a 1-1 draw under new coach Gabriele Cioffi.
They have only won one match in Serie A this season, but are also tough to break down, managing eight draws and three defeats.
Their absentee list is even longer than Roma’s, including Gerard Deulofeu, Kingsley Ehizibue, Keinan Davis, Brenner, Enzo Ebosse, Vivaldo Semedo and Thomas Kristensen.
Roberto Pereyra is a late addition and is not even on the bench.
Roma: Rui Patricio; Mancini, Llorente, Ndicka; Karsdorp, Paredes, Cristante, Pellegrini, Spinazzola; Dybala, Lukaku
Udinese: Silvestri; Ferreira, Bijol, Perez; Ebosele, Walace, Samardzic, Payero, Zemura; Thauvin, Success
Player statistic
| 19' |  |
João Ferreira | ||
| Gianluca Mancini (Assist: Paulo Dybala) |
 |
20' | ||
| 26' | |
Lazar Samardžić | ||
| 27' | |
Isaac Success | ||
| Lorenzo Pellegrini | |
33' |
| 57' | |
Florian Thauvin (Assist: Martín Payero) | ||
| Paulo Dybala (Assist: Romelu Lukaku) |
|
81' | ||
| Stephan El Shaarawy (Assist: Edoardo Bove) |
|
90' |
Match statistic
