Roma are forced into numerous changes as they try to get back into the fight for the top four with Paulo Dybala and Tammy Abraham against a revitalised Sampdoria.
It kicks off at the Stadio Olimpico at 17.00 UK time (16.00 GMT).
The Giallorossi went into the break for international duty amid tension, with Jose Mourinho suspended and back-to-back defeats in Serie A against Sassuolo and arch-rivals Lazio.
Mou returns to the touchline, but Bryan Cristante, Marash Kumbulla, Gianluca Mancini and Roger Ibanez are all banned now, plus Rick Karsdorp injured.
With practically his entire defence missing, the Special One has to reshuffle for a four-man defence, but at least he has Dybala, Lorenzo Pellegrini and Abraham upfront.
Sampdoria are still in penultimate place, but were boosted by a 3-1 victory over Verona going into the break.
It is a reunion for coach Dejan Stankovic with his Treble-winning Inter boss Mourinho on the touchline.
Bram Nuytinck is suspended and the goalkeeper situation is a full-blown crisis, as Emil Audero has a dislocated shoulder and replacement Martin Turk is suffering with flu symptoms.
Koray Gunter, Abdelhamid Sabiri, Ignacio Pussetto, Manuel De Luca and Andrea Conti are also on the treatment table.
Roma: Rui Patricio; Zalewski, Smalling, Llorente, Spinazzola; Matic, Wijnaldum; Dybala, Pellegrini, El Shaarawy; Abraham
Sampdoria: Ravaglia; Zanoli, Murillo, Amione; Leris, Winks, Rincon, Augello; Djuricic, Cuisance; Gabbiadini
Player statistic
| Tammy Abraham |  |
8' | ||
| 11' | |
Jeison Murillo | ||
| Leonardo Spinazzola | |
21' |
| 49' | |
Alessandro Zanoli | ||
| 52' |  |
Jeison Murillo | ||
| Georginio Wijnaldum (Assist: Nemanja Matic) |
 |
57' | ||
| Chris Smalling | |
60' | ||
| 68' | |
Flavio Paoletti | ||
| 70' | |
Harry Winks | ||
| Paulo Dybala |  |
88' | ||
| Stephan El Shaarawy (Assist: Ola Solbakken) |
|
90+4' |
Match statistic
