It kicks off at the Stadio Olimpico at 17.30 UK time (16.30 GMT).
There will be a minute’s silence ahead of kick-off after the death of legendary Roma coach Carlo Mazzone.
Both Jose Mourinho and his assistant Salvatore Foti sit out touchline bans, so director Bruno Conti will be on the bench for the first time since his caretaker role 18 years ago.
Paulo Dybala and Lorenzo Pellegrini are also suspended, with Tammy Abraham and Marash Kumbulla out for six months with knee ligament injuries.
New buys Evan N’Dicka, Leandro Paredes and Renato Sanches are not considered ready to start, so the options are extremely limited.
Salernitana are missing Flavius Daniliuc and Emil Bohinen, with Matteo Lovato not at 100 per cent.
Roma: Rui Patricio; Mancini, Smalling, Llorente; Kristensen, Bove, Cristante, Aouar, Spinazzola; El Shaarawy, Belotti
Salernitana: Ochoa; Lovato, Gyomber, Fazio; Mazzocchi, L Coulibaly, Maggiore, Bradaric; Kastanos, Candreva; Botheim