Victor Osimhen and Kvicha Kvaratskhelia take on Tammy Abraham and Nicolò Zaniolo in a fascinating Derby del Sole, as leaders Napoli protect their unbeaten record with a difficult trip to Jose Mourinho’s Roma.
It kicks off at the Stadio Olimpico at 19.45 UK time (18.45 GMT).
The Partenopei are the form team in Europe right now, on a run of 10 consecutive victories in all competition.
Amir Rrahmani and Andre-Frank Zambo Anguissa are out injured, but Osimhen is in the starting XI for the first time since that thigh injury against Liverpool.
Kvaratskhelia is the big danger man, having contributed seven goals and eight assists in 14 competitive matches for Napoli this season.
Roma are still missing Paulo Dybala, Marash Kumbulla, Zeki Celik, Georginio Wijnaldum and Ebrima Darboe, but Rick Karsdorp returns and Mady Camara is chosen in midfield rather than Nemanja Matic.
Abraham and Zaniolo lead the attack, with Lorenzo Pellegrini in a deeper midfield role.
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Cristante, Camara, Pellegrini, Spinazzola; Zaniolo, Abraham
Napoli: Meret; Di Lorenzo, Kim Min-jae, Juan Jesus, Olivera; Ndombele, Lobotka, Zielinski; Lozano, Osimhen, Kvaratskhelia