Paulo Dybala, Tammy Abraham and Lorenzo Pellegrini try to keep the Roma momentum going with Andrea Belotti on the bench, as Monza turn to Matteo Pessina.
It kicks off at the Stadio Olimpico at 19.45 UK time (18.45 GMT).
The Giallorossi are joint top of the table on seven points after back-to-back 1-0 wins over Salernitana and Cremonese, then a 1-1 draw away to Juventus.
Nicolò Zaniolo is still out of action with Georginio Wijnaldum and Ebrima Darboe long-term absentees, but new signing Belotti is on the bench.
Pellegrini and Dybala support Abraham, with changes on the flanks bringing in Nicola Zalewski and Zeki Celik.
Silvio Berlusconi invested millions in getting Monza to their first Serie A campaign and is already threatening to sack coach Giovanni Stroppa after three consecutive defeats.
Andrea Ranocchia, Marco D’Alessandro and Pablo Mari are injured, with Dany Mota Carvalho returning to the bench.
There is the first start for ex-Atalanta midfielder Pessina, finally fit to represent his hometown club.
Roma: Rui Patricio; Mancini, Kumbulla, Ibanez; Celik, Cristante, Matic, Zalewski; Dybala, Pellegrini; Abraham
Monza: Di Gregorio; Marlon, Marrone, Caldirola; Birindelli, Sensi, Pessina, Machin, Carlos Augusto; Petagna, Caprari
The match will be won 3:0 by Roma fc.