Jose Mourinho will be on the Roma bench after winning his appeal and Paulo Dybala faces his former club as a False 9, while Juventus look to Angel Di Maria and Dusan Vlahovic.
It kicks off at the Stadio Olimpico at 19.45 GMT.
You can follow all the build-up and action as it happens from today’s Serie A games on the LIVEBLOG.
Mourinho had originally been given a two-match ban for his touchline row with fourth official Marco Serra during the 2-1 defeat to Cremonese, but that was suspended following an appeal.
Tammy Abraham was expected to be back after recovering from a nasty cut under his eye, though Lorenzo Pellegrini has flu symptoms and Ola Solbakken a muscular issue in training.
Instead, Pellegrini and Gini Wijnaldum start in support of False 9 Dybala against the club he left as a free agent last summer.
Chris Smalling returns from suspension to bolster the defence.
Juve have won their last four Serie A matches on the trot and are closing on the Champions League places even with a 15-point penalty.
Arkadiusz Milik, Mattia De Sciglio and Kaio Jorge remain on the treatment table, but Paul Pogba made his season debut last week and is hoping to come off the bench along with Federico Chiesa in the second half.
Locatelli returns from suspension, supporting Di Maria and Vlahovic.
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Zalewski, Matic, Cristante, Spinazzola; Pellegrini, Wijnaldum; Dybala
Juventus: Szczesny; Danilo, Bremer, Alex Sandro; Cuadrado, Fagioli, Locatelli, Rabiot, Kostic; Di Maria, Vlahovic
Player statistic
| 31' |  |
Manuel Locatelli | ||
| Nemanja Matic | |
33' |
| Gianluca Mancini (Assist: Bryan Cristante) |
 |
54' | ||
| Bryan Cristante | |
58' | ||
| Leonardo Spinazzola | |
63' | ||
| 75' | |
Filip Kostic | ||
| 90' |  |
Moise Kean |
Match statistic
