Romelu Lukaku faces his former Inter teammates Lautaro Martinez and Hakan Calhanoglu, with Paulo Dybala also having a close call as Roma seek a fourth straight win.
It kicks off at the Stadio Olimpico at 17.00 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Giallorossi have been completely revitalised since Daniele De Rossi replaced Jose Mourinho, winning all three matches, including a 4-0 over Cagliari.
Tammy Abraham and Leonardo Spinazzola are still out of action, with Evan Ndicka at the Africa Cup of Nations, but Sardar Azmoun returns from Asian Cup duty and Chris Smalling is back on the bench too.
It’s not the same starting XI as last week, as Dean Huijsen replaces Diego Llorente with January signing Angeliño.
The trident is Dybala, Lukaku and Stephan El Shaarawy.
While Lukaku is a former Inter player who left in tense circumstances, Dybala had been on the verge of joining them too until they passed and the free agent went to Roma instead.
Inter coach Simone Inzaghi sits out a touchline ban, with Davide Frattesi, Stefano Sensi and Juan Cuadrado all injured, so they are a little short-staffed in midfield.
It’s the same starting XI that beat Juventus and a win here would let them temporarily go seven points clear at the top of the table.
Marcus Thuram replaced Lukaku and formed a great strike partnership with Lautaro Martinez.
Roma: Rui Patricio; Karsdorp, Mancini, Huijsen, Angelino; Cristante, Paredes, Pellegrini; Dybala, Lukaku, El Shaarawy
Inter: Sommer; Pavard, Acerbi, Bastoni; Darmian, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Lautaro Martinez
Player statistic
| 17' |  |
Francesco Acerbi | ||
| Gianluca Mancini (Assist: Lorenzo Pellegrini) |
|
28' | ||
| Stephan El Shaarawy (Assist: Lorenzo Pellegrini) |
|
44' |
| Gianluca Mancini |  |
47' | ||
| 49' | |
Marcus Thuram (Assist: Matteo Darmian) | ||
| 56' |  |
Angeliño | ||
| Dean Huijsen | |
90+1' | ||
| 90+3' | |
Alessandro Bastoni (Assist: Marko Arnautovic) |
Match statistic
