A new strike partnership is born, as Romelu Lukaku and Paulo Dybala start together for the first time, while Evan N’Dicka gets his Serie A debut when Roma host rock bottom Empoli.
It kicks off at the Stadio Olimpico at 19.45 UK time (18.45 GMT).
The Giallorossi had a disastrous start to the season, drawing 2-2 with Salernitana, then suffering back-to-back defeats against Verona and 10-man Milan.
Injury problems continue to pile up, as Houssem Aouar, Lorenzo Pellegrini and Chris Smalling join Tammy Abraham and Marash Kumbulla in the stands, but the good news for Jose Mourinho is that Lukaku and Dybala are both ready for their first start together.
Leandro Paredes and Renato Sanches have also shaken off issues, while summer signing N’Dicka gets his Serie A debut in defence.
Empoli are bottom of the table, failing to pick up a single point or even score a goal.
Daniel Maldini and goalkeeper Elia Caprile are still out of action, while Mattia Destro is the surprise centre-forward.
Roma: Rui Patricio; Mancini, Llorente, Ndicka; Kristensen, Cristante, Paredes, Renato Sanches, Spinazzola; Dybala, Lukaku
Empoli: Berisha; Bereszynski, Walukiewicz, Luperto, Pezzella; Maleh, Grassi, Fazzini; Cancellieri, Destro, Cambiaghi
Player statistic
| Paulo Dybala |  |
2' | ||
| Renato Sanches (Assist: Rasmus Kristensen) |
 |
8' | ||
| Alberto Grassi |  |
35' | ||
| Paulo Dybala |  |
38' | ||
| Renato Sanches | |
39' | ||
| 39' | |
Matteo Cancellieri |
| Paulo Dybala (Assist: Bryan Cristante) |
|
55' | ||
| 58' | |
Youssef Maleh | ||
| Bryan Cristante (Assist: Andrea Belotti) |
|
80' | ||
| Romelu Lukaku (Assist: Andrea Belotti) |
|
82' | ||
| Gianluca Mancini (Assist: Bryan Cristante) |
|
86' |
Match statistic
