Roma are still reeling from the Georginio Wijnaldum injury, but again use Paulo Dybala, Nicolò Zaniolo and Tammy Abraham together against Cremonese.
It kicks off at the sold out Stadio Olimpico at 17.30 UK time (16.30 GMT).
The Giallorossi started their campaign with a 1-0 win away to Salernitana, which saw Wijnaldum come off the bench for his competitive debut.
That might be his last game for a while, because he fractured his tibia in training yesterday and is expected to be out for three months.
Ebrima Darboe is also out for several months, but Bryan Cristante and Lorenzo Pellegrini retain their midfield spots with Nemanja Matic on the bench.
Cremonese were only beaten 3-2 by Fiorentina with the last kick of the game last week thanks to a Ionut Radu howler, so are not to be taken lightly.
Gonzalo Escalante is suspended, with Michele Castagnetti injured, but new signings Emanuel Aiwu, Luka Lochosvili and Santiago Asacibar start with strikers Cyriel Dessers and David Okereke.
Dessers will be out for revenge, seeing as he was in the Feyenoord side that lost the Europa Conference League Final to Roma.
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Pellegrini, Cristante, Spinazzola; Dybala, Zaniolo; Abraham
Cremonese: Radu; Aiwu, Chiriches, Lochoshvili; Ghiglione, Pickel, Ascacibar, Valeri; Zanimacchia; Dessers, Okereke