Roma have Nicolò Zaniolo back with Paulo Dybala and Tammy Abraham, while Atalanta revamp their attack again in this top of the table clash.
It kicks off at the Stadio Olimpico at 17.00 UK time (16.00 GMT).
There is one point separating these sides going into the weekend, as Atalanta are joint leaders with Milan and Napoli, followed by Roma and Udinese.
The Giallorossi got back on track in the Europa League midweek and that also marked Zaniolo’s comeback after almost a month out with a dislocated shoulder.
Dybala and Abraham were rested, but are back today, though Rick Karsdorp joins Marash Kumbulla, Stephan El Shaarawy, Georginio Wijnaldum and Ebrima Darboe on the treatment table.
Atalanta make the trip without Duvan Zapata, Davide Zappacosta, Nadir Zortea and Berat Djimsiti, plus Jose Luis Palomino, who failed a pre-season doping test.
Luis Muriel and Jeremie Boga are available despite knocks.
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Celik, Cristante, Pellegrini, Spinazzola; Zaniolo, Dybala; Abraham
Atalanta: Musso; Scalvini, Demiral, Toloi; Hateboer, De Roon, Koopmeiners, Maele; Ederson, Pasalic; Hojlund