Milan are without Alvaro Morata, so surprise with Noah Okafor, Rafael Leao, Christian Pulisic and new signing Strahinja Pavlovic for the trip to impressive Parma.
It kicks off at the Stadio Tardini at 17.30 UK time (16.30 GMT).
This match will make history as the first Serie A game to be shown live on broadcast television, airing on CBS in the United States of America.
The Rossoneri had a rude awakening in Week 1, fighting back from 2-0 down to scrape a last-gasp 2-2 draw with Torino at San Siro.
Morata picked up an injury in that game, so joins Alessandro Florenzi and Marco Sportiello on the treatment table.
Having come off the bench to score the stoppage-time equaliser, Okafor gets a rare start upfront, with Ruben Loftus-Cheek moved into a more advanced role.
New buys Emerson Royal and Youssouf Fofana are on the bench for the first time, but Pavlovic gets his debut in defence.
Parma opened their season with a Coppa Italia exit to Palermo and 1-1 Serie A draw against Fiorentina.
Hernani, Yordan Osorio, Adrian Benedyczak and Gabriel Charpentier are injured, but Enrico Delprato returns from suspension.
Romania internationals Dennis Man and Valentin Mihaila start, with rapid 20-year-old Ange-Yoan Bonny as the centre-forward.
Parma vs. Milan line-ups
Parma: Suzuki; Coulibaly, Balogh, Circati, Valeri; Estevez, Sohm; Man, Bernabé, Mihaila; Bonny
Milan: Maignan; Calabria, Tomori, Pavlovic, Theo Hernandez; Musah, Reijnders; Pulisic, Loftus-Cheek, Leao; Okafor
Player statistic
| Dennis Man (Assist: Emanuele Valeri) |
 |
2' | ||
| 34' |  |
Strahinja Pavlovic |
| 66' | |
Christian Pulisic (Assist: Rafael Leão) | ||
| Matteo Cancellieri (Assist: Pontus Almqvist) |
|
77' | ||
| 88' | |
Emerson Royal | ||
| 90+2' | |
Ruben Loftus-Cheek |
Match statistic
