Napoli have Lorenzo Insigne back in the starting XI with Victor Osimhen against Gerard Deulofeu and Beto’s Udinese.
It kicks off at the Stadio Diego Armando Maradona at 14.00 GMT.
Serie A Liveblog: Napoli-Udinese, Inter-Fiorentina, Cagliari-Milan
The Partenopei go into the weekend in second place, three points behind leaders Milan, although Inter in third have a game in hand.
Insigne has shaken off a knock after the 2-0 win away to Verona and returns to the starting XI with Osimhen, who scored twice at the Stadio Bentegodi.
There’s still no room for Piotr Zielinski, as the 4-2-3-1 has moved to 4-3-3 in recent weeks.
Alex Meret, Andrea Petagna, Kevin Malcuit and Adam Ounas are on the treatment table.
Udinese miss Isaac Success and Nehuen Perez, but Walace returns from suspension after missing the 1-1 draw with Roma.
Deulofeu and Beto lead the attack with Roberto Pereyra and Nahuel Molina to watch.
Napoli: Ospina; Di Lorenzo, Rrahmani, Koulibaly, Mario Rui; Anguissa, Lobotka, Fabian Ruiz; Politano, Osimhen, Insigne
Udinese: Silvestri; Becao, Pablo Mari, Zeegelaar; Molina, Pereyra, Walace, Makengo, Udogie; Deulofeu, Beto