Napoli start Giacomo Raspadori and Kvicha Kvaratskhelia as they try to hang on to the top of the Serie A table, but Torino have had a solid start to the season too.
It kicks off at the Stadio Diego Armando Maradona at 14.00 UK time (13.00 GMT).
The Partenopei went into the break for international duty on level terms with Atalanta following their 2-1 win away to Milan.
Victor Osimhen is still out injured, so after his fine work for Italy, Raspadori gets the nod rather than Giovanni Simeone this time around, partnered by Kvaratskhelia and Matteo Politano, the latter recovering after he had to withdraw from the Italy camp.
They are wearing their new Halloween-themed strip.
Torino make the trip without injured Pietro Pellegri, Samuele Ricci and Mergim Vojvoda, but Aleksei Miranchuk is back in the squad.
Antonio Sanabria returns to the starting XI with support from Nikola Vlasic.
The Granata have not won in Naples since a 2-1 result in May 2009, followed by four draws and six defeats.
Napoli: Meret; Di Lorenzo, Rrahmani, Kim Min-jae, Mario Rui; Anguissa, Lobotka, Zielinski; Politano, Raspadori, Kvaratskhelia
Torino: Milinkovic-Savic; Djidji, Buongiorno, Rodriguez; Singo, Lukic, Linetty, Lazaro; Vlasic, Miranchuk; Sanabria