Napoli again use Dries Mertens in support of Victor Osimhen as they try to get back on track against Domenico Berardi’s Sassuolo.
It kicks off at the Stadio Diego Armando Maradona at 14.00 UK time (13.00 GMT).
You can follow all the build-up and action as it happens from today’s four Serie A games, including Cagliari–Verona at the same kick-off time, on the LIVEBLOG.
The Partenopei are under huge pressure after their dismal recent results saw them fall away from the Scudetto race, sitting just one point clear of Juventus in fourth place.
They managed only one draw in their last three games, fumbling a 2-0 lead at Empoli to lose 3-2 in 10 minutes.
Stanislav Lobotka and Adam Ounas are out of action, but Giovanni Di Lorenzo and David Ospina return.
Mertens again starts with Osimhen, Lorenzo Insigne and Hirving Lozano in a more attack-minded 4-2-3-1 formation.
Sassuolo have lost three of their last four matches, with Georgios Kyriakopoulos suspended, Jeremy Toljan, Hamed Junior Traore, Filippo Romagna and Abdou Harroui injured.
Berardi, Giacomo Raspadori and Filip Djuricic support Gianluca Scamacca.
Napoli: Ospina; Di Lorenzo, Rrahmani, Koulibaly, Mario Rui; Anguissa, Fabian Ruiz; Lozano, Mertens, Insigne; Osimhen
Sassuolo: Consigli; Muldur, Chiriches, Ferrari, Rogerio; Frattesi, Lopez; Berardi, Raspadori, Djuricic; Scamacca