Napoli conclude their triumphant Serie A season with Victor Osimhen already crowned Capocannoniere, partnered by Kvicha Kvaratskhelia against relegated Sampdoria.
It kicks off at the Stadio Diego Armando Maradona at 17.30 UK time (16.30 GMT).
The Partenopei will have a big party in the stadium after the final whistle, with the players receiving their medals and captain Giovanni Di Lorenzo lifting the Serie A trophy to the sky, the first Napoli player to do so since Diego Maradona in 1990.
Luciano Spalletti is also bound to be emotional as he waves goodbye to the fans, while Kim Min-jae is suspended, but also likely to move on.
Matteo Politano, Hirving Lozano and Mathias Olivera are carrying knocks, but Mario Rui returns.
Sampdoria are rock bottom, but had some good news this week with the imminent takeover by Leeds United President Andrea Radrizzani, saving the club from bankruptcy.
Emil Audero, Sam Lammers, Ignacio Pussetto, Abdelhamid Sabiri, Harry Winks, Jeison Murillo and Michael Cuisance are all out of action.
It should be a special moment for Fabio Quagliarella, expected to hang up his boots in his hometown.
Napoli: Meret; Di Lorenzo, Rrahmani, Ostigard, Mario Rui; Anguissa, Lobotka, Zielinski; Elmas, Osimhen, Kvaratskhelia
Sampdoria: Turk; Gunter, Murru, Amione; Zanoli, Paoletti, Rincon, Leris, Augello; Gabbiadini, Quagliarella
Player statistic
| 63' |  |
Nicola Murru | ||
| Victor Osimhen |  |
64' | ||
| Giovanni Simeone (Assist: Giacomo Raspadori) |
 |
85' |
Match statistic
