Napoli have the opportunity to go 13 points clear at the top of the table with Victor Osimhen and returning Kvicha Kvaratskhelia, but Jose Mourinho’s Roma bring Paulo Dybala and Tammy Abraham to put Nicolò Zaniolo out of their minds.
It kicks off at the Stadio Diego Armando Maradona at 19.45 GMT.
Luciano Spalletti is potentially running away with the Scudetto and with Milan losing to Sassuolo today and Juventus docked 15 points, a win here would extend their lead at the top to 13 points.
He also has a full squad to choose from, as Kvaratskhelia has shaken off flu symptoms to start upfront with Capocannoniere Osimhen and Chucky Lozano.
Roma go into this game with a great deal of tension behind the scenes after Zaniolo put in a transfer request, then turned down the move to Bournemouth, so may well be stuck there for six months.
He is frozen out along with fellow rebel Rick Karsdorp, plus Georginio Wijnaldum injured and Zeki Celik suspended, so Leonardo Spinazzola takes the left wing.
Despite everything, the Giallorossi are right in the thick of the race for a Champions League spot, unbeaten in six including back-to-back victories over Fiorentina and Spezia.
Napoli: Meret; Di Lorenzo, Rrahmani, Kim Min-jae, Mario Rui; Anguissa, Lobotka, Zielinski; Lozano, Osimhen, Kvaratskhelia
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Zalewski, Cristante, Matic, Spinazzola; Pellegrini, Dybala; Abraham