Victor Osimhen and Kvicha Kvaratskhelia hope to keep Napoli in the race for Europe, while reshuffled Roma cannot afford to drop more points with Paulo Dybala and the return of Evan Ndicka.
It kicks off at the Stadio Diego Armando Maradona at 17.00 UK time (16.00 GMT).
The reigning champions had a disastrous campaign with three different coaches and face a fight just to qualify for Europe following a draw with Frosinone and defeat to Empoli.
Piotr Zielinski and Pierluigi Gollini are carrying injuries, but Mario Rui and Amir Rrahmani return from suspension.
Matteo Politano completes the trident attack with Osimhen and Kvaratskhelia.
Roma grabbed a last-gasp win over Udinese in the mini-match on Thursday, finishing the fixture that was interrupted by Ndicka being taken ill.
Leandro Paredes and Diego Llorente are suspended, with Romelu Lukaku and Chris Smalling not fully fit.
Sardar Azmoun therefore starts upfront again with Dybala and Stephan El Shaarawy.
The big news is the return of Ndicka in the starting XI, his first appearance since his hospitalisation with chest pains, which turned out to be caused by a collapsed lung.
Napoli vs. Roma line-ups
Napoli: Meret; Di Lorenzo, Rrahmani, Juan Jesus, Olivera; Anguissa, Lobotka, Cajuste; Politano, Osimhen, Kvaratskhelia
Roma: Svilar; Kristensen, Mancini, Ndicka, Spinazzola; Bove, Cristante, Pellegrini; Dybala, Azmoun, El Shaarawy
Player statistic
| 59' |  |
Paulo Dybala | ||
| Mathías Olivera (Assist: Jens Cajuste) |
 |
64' | ||
| Amir Rrahmani |  |
75' | ||
| Frank Anguissa | |
80' | ||
| Victor Osimhen | |
84' | ||
| 88' | |
Tammy Abraham (Assist: Evan Ndicka) |
Match statistic
