Napoli give David Neres his first start with Scott McTominay, Billy Gilmour and Romelu Lukaku as the leaders host troubled Lecce.
It kicks off at the Stadio Diego Armando Maradona at 14.00 UK time (13.00 GMT).
And find out where to watch live here.
The Partenopei are top of the Serie A table and hope to further consolidate their lead, especially as Inter and Juventus go head-to-head tomorrow night.
Alex Meret returns after more than a month out with injury, while super-sub Neres finally gets his first start alongside Lukaku and Cyril Ngonge.
Khvicha Kvaratskhelia and Matteo Politano are among those rested.
Gilmour continues to stand in for injured Stanislav Lobotka with fellow Scotland international McTominay in midfield.
Lecce are still reeling after their embarrassing 6-0 home defeat to Fiorentina, where Antonino Gallo saw red early and is therefore suspended.
Injuries are piling up too for Frederic Guilbert, Kevin Bonifazi, Medon Berisha, Luis Hasa and Filip Marchwinski.
They are without a win since Week 3, followed by two draws and three consecutive defeats, scoring in only one of those matches.
Napoli vs. Lecce line-ups
Napoli: Meret; Di Lorenzo, Rrahmani, Buongiorno, Olivera; Anguissa, Gilmour, McTominay; Ngonge, Lukaku, David Neres
Lecce: Falcone; Pelmard, Gaspar, Baschirotto, Dorgu; L Coulibaly, Ramadani, Rafia; Banda, Krstovic, Pierotti
