Napoli rely on Victor Osimhen and Kvicha Kvaratskhelia as they bit to extend their Serie A lead even more, while Mattia Zaccagni is back with Ciro Immobile for fourth-placed Lazio.
It kicks off at the Stadio Diego Armando Maradona at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Partenopei are already 18 points clear at the top of the table and on their way towards a Scudetto that Maurizio Sarri came close to, but could not deliver.
Luciano Spalletti is on the verge of taking the title, as well as preparing for the second leg of the Champions League Round of 16 against Eintracht Frankfurt.
Giacomo Raspadori is injured and Mario Rui suspended, so Matias Olivera steps in with Chucky Lozano completing the trident attack.
Lazio look as ever to top scorer and native Neapolitan Ciro Immobile, who is supported by Felipe Anderson and Zaccagni, the latter returning after a stomach bug.
Alessio Romagnoli and Patric are both carrying issues going in, but start anyway, with Stefan Radu out of action.
Napoli have won each of their last four meetings with Lazio, while the Aquile have not managed a victory in Campania since the 4-2 result in May 2015.
Napoli: Meret; Di Lorenzo, Rrahmani, Kim Min-jae, Olivera; Anguissa, Lobotka, Zielinski; Lozano, Osimhen, Kvaratskhelia
Lazio: Provedel; Marusic, Patric, Romagnoli, Hysaj; Milinkovic-Savic, Vecino, Luis Alberto; Felipe Anderson, Immobile, Zaccagni
Player statistic
| 21' |  |
Patric |
| Victor Osimhen | |
63' | ||
| 67' |  |
Matías Vecino | ||
| Eljif Elmas | |
89' | ||
| 90+4' | |
Adam Marusic |
Match statistic
