Kvicha Kvaratskhelia is back in the starting XI with Victor Osimhen for reigning champions Napoli, as Maurizio Sarri hopes Ciro Immobile can get Lazio’s first points of the season.
It kicks off at the Stadio Diego Armando Maradona at 19.45 UK time (18.45 GMT).
The Partenopei have had the perfect opening to the campaign and have Kvaratskhelia making his first start after a minor injury, completing the trident with Osimhen and Matteo Politano.
Pierluigi Gollini is the only absentee with a bruised hand.
Lazio lost both matches against Lecce and Genoa, so are rock bottom of the table with only one goal scored.
Pedro is struggling with an ankle knock, so Felipe Anderson joins Immobile and Mattia Zaccagni upfront.
Daichi Kamada is again preferred to Matias Vecino in midfield.
This is a return to Naples for Sarri, who was on their bench from 2015 to 2018.
Napoli: Meret; Di Lorenzo, Rrahmani, Juan Jesus, Olivera; Anguissa, Lobotka, Zielinski; Politano, Osimhen, Kvaratskhelia
Lazio: Provedel; Marusic, Casale, Romagnoli, Hysaj; Kamada, Cataldi, Luis Alberto; Felipe Anderson, Immobile, Zaccagni
Player statistic
| 26' |  |
Mattia Zaccagni | ||
| 30' |  |
Luis Alberto (Assist: Felipe Anderson) | ||
| Piotr Zielinski | |
32' |
| 52' | |
Daichi Kamada (Assist: Felipe Anderson) | ||
| 60' | |
Luis Alberto |
Match statistic
