Napoli are unbeaten under coach Francesco Calzona and hope Victor Osimhen and Kvicha Kvaratskhelia can keep their form going against Dusan Vlahovic and Federico Chiesa’s Juventus.
It kicks off at the Stadio Diego Armando Maradona at 19.45 GMT.
The Partenopei won this fixture 5-1 last season on their way to winning the Scudetto, but so much has changed since then, as they are on their third coach of the season and struggling to get back into the race for a top four finish.
Calzona is unbeaten, as after draws with Barcelona and Cagliari, he flattened Sassuolo 6-1 last week with an Osimhen hat-trick and Kvaratskhelia brace.
Jens Cajuste and January signing Cyril Ngonge are still out injured, so Hamed Junior Traore takes the midfield reins.
Juventus are forced to do without Adrien Rabiot, Weston McKennie, Moise Kean, Mattia Perin and Mattia De Sciglio, while Paul Pogba was given a four-year doping ban this week.
Max Allegri therefore gives January loanee Carlos Alcaraz his first start, with Samuel Iling Junior given the nod rather than Filip Kostic on the left.
Chiesa is finally ready to start again after a series of niggling injuries, partnering on-form Vlahovic.
Napoli: Meret; Di Lorenzo, Rrahmani, Juan Jesus, Olivera; Anguissa, Lobotka, Traorè; Politano, Osimhen, Kvaratskhelia
Juventus: Szczesny; Bremer, Rugani, Alex Sandro; Cambiaso, Alcaraz, Miretti, Locatelli, Iling Jr; Vlahovic, Chiesa
Player statistic
| 18' |  |
Dusan Vlahovic | ||
| 26' | |
Bremer | ||
| 28' | |
Andrea Cambiaso | ||
| Khvicha Kvaratskhelia |  |
42' |
| Hamed Junior Traorè | |
47' | ||
| 81' | |
Federico Chiesa (Assist: Carlos Alcaraz) | ||
| 86' | |
Joseph Nonge | ||
| Victor Osimhen |  |
88' | ||
| Giacomo Raspadori | |
88' |
Match statistic
