Victor Osimhen returns to the Napoli starting XI with Kvicha Kvaratskhelia as Walter Mazzarri tries to stall Inter’s Lautaro Martinez and Marcus Thuram.
It kicks off at the Stadio Diego Armando Maradona at 19.45 GMT.
The Partenopei are the reigning Champions of Italy, but lost coach Luciano Spalletti, then sacked Rudi Garcia and brought in Mazzarri after a 10-year absence.
He won his debut away to Atalanta and lost 4-2 to Real Madrid in the Champions League midweek, but has Osimhen finally ready to start two months after a thigh strain on international duty.
With Mario Rui and Mathias Olivera injured, Natan is moved to left-back, while Piotr Zielinski is not at 100 per cent after being on the end of an Antonio Rudiger horror tackle.
Inter drew with Benfica when resting eight star names, who all return here, save for the injured Alessandro Bastoni and Benjamin Pavard.
Thuram and Capocannoniere Lautaro Martinez lead the way, with a win needed to recapture top spot from Juventus.
The Nerazzurri have a surprisingly poor record in this fixture, as the 3-1 victory in January 2020 was the only Serie A success away to Napoli in the last 35 years.
Napoli: Meret; Di Lorenzo, Rrahmani, Ostigard, Natan; Anguissa, Lobotka, Elmas; Politano, Osimhen, Kvaratskhelia
Inter: Sommer; Darmian, De Vrij, Acerbi; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Lautaro Martinez
Player statistic
| 44' |  |
Hakan Calhanoglu (Assist: Nicolò Barella) |
| Eljif Elmas |  |
58' | ||
| 61' | |
Nicolò Barella (Assist: Lautaro Martínez) | ||
| Amir Rrahmani | |
73' | ||
| 78' | |
Matteo Darmian | ||
| 85' | |
Marcus Thuram (Assist: Juan Cuadrado) | ||
| 85' | |
Marcus Thuram |
Match statistic
