Napoli are still without Victor Osimhen, but have Alex Meret, Natan and debutant Hamed Junior Traore starting against Mateo Retegui and Albert Gudmundsson’s high-flying Genoa.
It kicks off at the Stadio Diego Armando Maradona at 14.00 GMT.
The Partenopei are coming off a 1-0 defeat to Milan, which left them in 10th place with a game in hand.
Victor Osimhen only returned from AFCON duty on Friday, so is not even on the bench, hoping to be ready for Wednesday’s Champions League Round of 16 tie against Barcelona.
Juan Jesus is suspended, but Natan and Mario Rui are available again, along with returning goalkeeper Meret.
January signing Traore gets his debut in midfield, despite the fact Piotr Zielinski is off the UEFA list, as Walter Mazzarri shifts tactics yet again to the 4-3-3.
Giovanni Simeone is once more preferred to Giacomo Raspadori, flanked by Kvicha Kvaratskhelia and Matteo Politano.
Genoa had been unbeaten in eight rounds until the defeat to Atalanta, so are eager to get back on track.
Koni De Winter returns from suspension, but Alan Matturro is out for the rest of the season following surgery.
Junior Messias pulls the strings behind Retegui and Gudmundsson, benching Ruslan Malinovskyi.
Napoli: Meret; Di Lorenzo, Rrahmani, Ostigard, Mazzocchi; Anguissa, Lobotka, Traore; Politano, Simeone, Kvaratskhelia
Genoa: Martinez; De Winter, Bani, Vasquez; Sabelli, Badelj, Frendrup, Messias, Martin; Gudmundsson, Retegui
Player statistic
| Leo Östigard |  |
26' | ||
| Khvicha Kvaratskhelia | |
42' |
| 47' |  |
Morten Frendrup | ||
| 50' | |
Johan Vásquez | ||
| Giovanni Di Lorenzo | |
54' | ||
| Cyril Ngonge (Assist: Giovanni Di Lorenzo) |
|
90' | ||
| 90+3' | |
Vitinha |
Match statistic
