Napoli try to get back into the race for European qualification with Victor Osimhen and Kvicha Kvaratskhelia, but Frosinone are fighting for survival with Matias Soule.
It kicks off at the Stadio Diego Armando Maradona at 11.30 UK time (10.30 GMT).
The Partenopei were in crisis with two points from three rounds, but fought back to hammer Monza 4-2 last week and rediscover some confidence.
The slowdown of the teams ahead of them in the table also keeps the door open for a sprint finish to get into Europe.
Cyril Ngonge is suspended, with Mathias Olivera and Juan Jesus carrying injuries, so the defence has to be revamped.
Matteo Politano returns to complete the trident with Osimhen and Kvaratskhelia.
Frosinone plummeted into the bottom three after a dire run of four draws in 10 rounds, but were able to hold Bologna 0-0 last week.
Ilario Monterisi, Abdou Harroui, Kevin Bonifazi, Anthony Oyono and Sergio Kalaj are out of action.
Soule is the star man, but it is a special game for Walid Cheddira, who is on loan from Napoli.
Napoli: Meret; Di Lorenzo, Ostigard, Rrahmani, Mario Rui; Anguissa, Lobotka, Zielinski; Politano, Osimhen, Kvaratskhelia
Frosinone: Turati; Lirola, Okoli, Romagnoli, Zortea; Barrenechea, Mazzitelli, Valeri; Soule, Brescianini; Cheddira
Player statistic
| Matteo Politano (Assist: Giovanni Di Lorenzo) |
 |
16' | ||
| Amir Rrahmani |  |
29' | ||
| 30' |  |
Matìas Soulé |
| 50' | |
Walid Cheddira (Assist: Matìas Soulé) | ||
| Victor Osimhen (Assist: Khvicha Kvaratskhelia) |
|
63' | ||
| Mário Rui | |
66' | ||
| 73' | |
Walid Cheddira (Assist: Nadir Zortea) | ||
| Mário Rui |  |
90+7' | ||
| 90+6' | |
Caleb Okoli |
Match statistic
