Napoli are seeking a ninth consecutive Serie A home victory with Victor Osimhen and birthday boy Kvicha Kvaratskhelia, but are well aware Cremonese already knocked them out of the Coppa Italia.
It kicks off at the Stadio Diego Armando Maradona at 19.45 GMT.
The Partenopei went into this round 13 points clear at the top of the table and can temporarily make that 16, awaiting Inter’s match against Sampdoria on Monday night.
Luciano Spalletti has a full squad to choose from, including Capocannoniere Osimhen and Georgian winger Kvaratskhelia, who celebrates his 22nd birthday today.
Only Tanguy Ndombele is rested because his wife gave birth yesterday.
Cremonese are a curious case, as they are still without a single Serie A victory this season, but knocked Napoli and Roma out of the Coppa Italia, so will face Fiorentina in the semi-final in April.
There have been definite improvements since Davide Ballardini took over in January, and his debut was the extra time 2-2 draw in Naples, emerging victorious on penalties.
Cyriel Dessers, David Okereke, Matteo Bianchetti, Giacomo Quagliata, Cristian Buonaiuto and Luka Lochoshvili are out of action, so former Roma talent Felix Afena-Gyan starts.
Napoli: Meret; Di Lorenzo, Rrahmani, Kim Min-jae, Mario Rui; Anguissa, Lobotka, Zielinski; Lozano, Osimhen, Kvaratskhelia
Cremonese: Carnesecchi; Ferrari, Chiriches, Vasquez; Sernicola, Pickel, Benassi, Meité, Aiwu; Tsadjout, Afena-Gyan