Victor Osimhen and Kvicha Kvaratskhelia are supported by a revamped Napoli midfield against a Cagliari side who never stop surprising with their dramatic comebacks.
It kicks off at the Stadio Diego Armando Maradona at 17.00 GMT.
The Partenopei reached the Champions League Round of 16 with a midweek victory over SC Braga, but have lost two on the bounce in Serie A and need to get back on track to recapture a top four position.
Piotr Zielinski is the latest addition to the injury list with a knee problem, joining Eljif Elmas and Mathias Olivera, so Jens Cajuste steps into midfield.
Mario Rui is only fit for the bench after his lay-off, so Natan is confirmed at left-back.
Claudio Ranieri’s Cagliari are the comeback kings of Serie A, managing a series of dramatic late turnarounds, the most recent seeing Gianluca Lapadula and then Leonardo Pavoletti’s overhead kick beat Sassuolo in stoppages.
Pavoletti is launched from the start with Andrea Petagna and Gaetano Oristanio.
Antoine Makoumbou returns from suspension, but Eldor Shomurodov fractured a metatarsal in his foot, so joins Marko Rog and Elio Capradossi on the treatment table.
There is a minute’s silence before all games this weekend for former Napoli captain Antonio Juliano.
There were a few problems at the Stadio Maradona today caused by strong winds, so the entry of fans in some sectors was delayed while officials checked the roof for loose tiles.
Napoli: Meret; Di Lorenzo, Rrahmani, Juan Jesus, Natan; Anguissa, Lobotka, Cajuste; Politano, Osimhen, Kvaratskhelia
Cagliari: Scuffet; Nandez, Goldaniga, Dossena, Augello; Makoumbou, Prati, Jankto; Oristanio; Pavoletti, Petagna
Player statistic
| Victor Osimhen |  |
45' | ||
| Amir Rrahmani | |
45+4' | ||
| 45+2' | |
Edoardo Goldaniga | ||
| 45+3' | |
Leonardo Pavoletti |
| 63' | |
Tommaso Augello | ||
| Victor Osimhen (Assist: Mário Rui) |
 |
69' | ||
| 72' | |
Leonardo Pavoletti (Assist: Zito Luvumbo) | ||
| Khvicha Kvaratskhelia (Assist: Victor Osimhen) |
|
75' | ||
| Mário Rui | |
85' | ||
| Matteo Politano | |
88' | ||
| Frank Anguissa | |
90+1' |
Match statistic
