Victor Osimhen and Giacomo Raspadori lead the way for Napoli, while Atalanta start Ederson and Gianluca Scamacca.
It kicks off at the Stadio Diego Armando Maradona at 11.30 GMT.
Both sides had to deal with injury problems after their star men were away on international duty.
Kvicha Kvaratskhelia helped Georgia qualify for Euro 2024, but picked up a groin injury in the process and is out of action.
Osimhen, meanwhile, skipped the call-up from Nigeria due to a muscular issue and has now fully recovered.
Atalanta lost Charles De Ketelaere to a knock, and after leaving the Netherlands early, Teun Koopmeiners is not passed fit to start either.
Mario Pasalic and Aleksei Miranchuk therefore support Gianluca Scamacca.
This is a head-to-head for European ambitions, as Atalanta are in sixth place with a game in hand, two points clear of Napoli.
La Dea’s match with Fiorentina had to be rescheduled when director Joe Barone was taken ill and a minute’s silence will be held before all games this weekend.
Napoli: Meret; Di Lorenzo, Rrahmani, Juan Jesus, Mario Rui; Anguissa, Lobotka, Traorè; Politano, Osimhen, Raspadori
Atalanta: Carnesecchi; Scalvini, Hien, Kolasinac; Hateboer, De Roon, Ederson, Zappacosta; Pasalic; Miranchuk, Scamacca
Player statistic
| 26' |  |
Aleksey Miranchuk (Assist: Mario Pasalic) | ||
| Victor Osimhen |  |
38' | ||
| 45' | |
Gianluca Scamacca (Assist: Aleksey Miranchuk) |
| 54' | |
Sead Kolasinac | ||
| 82' | |
Teun Koopmeiners | ||
| Giovanni Di Lorenzo | |
84' | ||
| 88' | |
Teun Koopmeiners (Assist: Matteo Ruggeri) |
Match statistic
