Juventus are decimated and ring the changes as Max Allegri tries to emerge from this crisis against a Monza side making their debut under new coach Raffaele Palladino.
It kicks off at the U-Power Stadium at 14.00 UK time (13.00 GMT).
The pressure is growing on Allegri to deliver results and performances after a dismal start to the season, as while they had a last-gasp Arek Milik winner incorrectly disallowed by VAR against Salernitana, the fact they had to fight back from 2-0 down was enough to worry fans.
A midweek home defeat to Benfica in the Champions League only exacerbated matters.
Milik, Juan Cuadrado and coach Allegri all sit out bans, with Manuel Locatelli, Adrien Rabiot, Alex Sandro, Federico Chiesa, Paul Pogba and Kaio Jorge injured.
Angel Di Maria returns to the starting XI with Filip Kostic to support Dusan Vlahovic, while Leonardo Bonucci is rested in favour of Federico Gatti.
Monza picked up their historic first ever Serie A point last week against Lecce, but that wasn’t enough to stop Giovanni Stroppa’s dismissal.
Former Juventus winger Palladino is promoted from the youth team role to be their coach.
Andrea Petagna, Marco D’Alessandro and Andrea Ranocchia are unavailable.
Monza: Di Gregorio; Marlon, Pablo Marí, Izzo; Ciuriia, Rovella, Sensi, Carlos Augusto; Pessina, Mota, Caprari
Juventus: Perin; De Sciglio, Gatti, Bremer, Danilo; McKennie, Paredes, Miretti; Di Maria, Vlahovic, Kostic