Milan again look to Olivier Giroud and Rafael Leao amid an injury crisis, while Jose Mourinho picks Tammy Abraham, Paulo Dybala and Nicolò Zaniolo for Roma.
It kicks off at San Siro at 19.45 GMT.
The Rossoneri closed the gap on leaders Napoli midweek and hope to keep the defence of their title alive in this crucial showdown.
Stefano Pioli continues to deal with a packed treatment room, missing Mike Maignan, Ante Rebic, Fode Ballo-Toure, Rade Krunic, Divock Origi, Junior Messias, Alessandro Florenzi and Zlatan Ibrahimovic.
Brahim Diaz is again preferred to Charles De Ketelaere in support of Giroud and Leao.
Roma have the usual long-term absentees, Georginio Wijnaldum and Ebrima Darboe, with Rick Karsdorp frozen out, but Dybala and Zaniolo can start after knocks.
Abraham was benched for the slender win over Bologna and returns to the starting XI here.
Jose Mourinho is again in the stands on a touchline ban for dissent.
Milan: Tatarusanu; Calabria, Kalulu, Tomori, Theo Hernandez; Bennacer, Tonali; Saelemaekers, Brahim Diaz, Leao; Giroud
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Celik, Cristante, Pellegrini, Zalewski; Dybala, Zaniolo; Abraham