Milan return Theo Hernandez to left-back and revamp the midfield for this showdown with Roma, who start Stephan El Shaarawy with Romelu Lukaku and change in goal.
It kicks off at San Siro at 19.45 GMT.
You can follow all the build-up and action as it happens from today’s Serie A games on the LIVEBLOG.
The Rossoneri are eager to consolidate third place and this is a big clash for top four ambitions.
These teams and their coaches are also under pressure following midweek Coppa Italia quarter-final elimination, to Atalanta and Lazio respectively.
Milan’s injury crisis remains extensive, including Alessandro Florenzi, Marco Pellegrino, Tommaso Pobega, Pierre Kalulu, Malick Thiaw, Fikayo Tomori, Marco Sportiello and Mattia Caldara.
To make matters worse, Ismael Bennacer and Samuel Chukwueze are at the Africa Cup of Nations, though Noah Okafor has recovered for a spot on the bench.
The big change is that Theo Hernandez can return to his left-back role after weeks in central defence, while Yacine Adli steps in to midfield.
It allows Ruben Loftus-Cheek to push up into a trequartista role behind Olivier Giroud, with Christian Pulisic and Rafael Leao.
Roma lost Paulo Dybala to another muscular injury during the midweek Coppa Italia defeat to Lazio, joining Renato Sanches, Chris Smalling, Tammy Abraham and Marash Kumbulla on the treatment table.
Sardar Azmoun, Evan Ndicka and Houssem Aouar are all on international duty.
Lukaku is therefore partnered by former Rossoneri star Stephan El Shaarawy, while Dean Huijsen again starts in defence.
Zeki Celik gets the tough task of tracking Rafael Leao and Theo Hernandez down that flank.
The big surprise is that Rui Patricio is dropped in favour of goalkeeper Mile Svilar for the 24-year-old Serbian’s first Serie A start.
Jose Mourinho sits out a touchline ban following his red card for dissent in the draw with Atalanta.
Roma have not beaten Milan since October 2019, managing just three draws and five defeats, home and away.
Their last victory at San Siro was 2-0 back in October 2017.
Milan: Maignan; Calabria, Kjaer, Gabbia, Theo Hernandez; Adli, Reijnders; Pulisic, Loftus-Cheek, Leao; Giroud
Roma: Svilar; Kristensen, Mancini, Llorente; Celik, Cristante, Paredes, Bove, Spinazzola; Lukaku, El Shaarawy
Player statistic
| Yacine Adli (Assist: Tijjani Reijnders) |
 |
11' | ||
| 43' |  |
Gianluca Mancini |
| Olivier Giroud (Assist: Simon Kjaer) |
|
56' | ||
| 56' | |
Bryan Cristante | ||
| 69' |  |
Leandro Paredes | ||
| Simon Kjaer | |
71' | ||
| 81' | |
Dean Huijsen | ||
| Theo Hernández (Assist: Olivier Giroud) |
|
84' | ||
| Matteo Gabbia | |
90' |
Match statistic
we need positive result froza milan