Ismael Bennacer steps into the Milan midfield behind Rafael Leao, Christian Pulisic and Olivier Giroud, while Napoli give Kvicha Kvaratskhelia a new role behind Giovanni Simeone.
It kicks off at the Stadio Giuseppe Meazza, also known as San Siro, at 19.45 GMT.
You can follow all the build-up and action as it happens from today’s Serie A games on the LIVEBLOG.
The Rossoneri are on a roll and hope to start closing the gap on second-placed Juventus, but Tijjani Reijnders sits out a ban.
That means Bennacer and Yacine Adli start together for the first time in a new-look midfield.
Samuel Chukwueze is still at the Africa Cup of Nations, with Fikayo Tomori, Pierre Kalulu, Mattia Caldara and Tommaso Pobega injured.
Malick Thiaw returned to training this week after almost three months out.
Napoli have Mario Rui suspended, with Victor Osimhen playing for Nigeria in tonight’s Africa Cup of Nations Final.
The good news is the return of Piotr Zielinski and Mathias Olivera, with the Poland international back in the starting XI, despite the fact his contract is running down ahead of a move to Inter.
Alex Meret was in the squad, but is not even on the bench due to a stomach bug.
Walter Mazzarri brings back the three-man defence, but with Kvaratskhelia in a new free role behind sole striker Simeone, allowing him to roam and be less predictable.
Milan: Maignan; Calabria, Kjaer, Gabbia, Theo Hernandez; Adli, Bennacer; Pulisic, Loftus-Cheek, Leao; Giroud
Napoli: Gollini; Ostigard, Rrahmani, Juan Jesus; Di Lorenzo, Anguissa, Lobotka, Zielinski, Mazzocchi; Kvaratskhelia, Simeone
Player statistic
| Theo Hernández (Assist: Rafael Leão) |
 |
25' |
| 85' |  |
Juan Jesus | ||
| Theo Hernández | |
90+6' |
Match statistic
