Mike Maignan, Rafael Leao and Olivier Giroud return to the Milan starting XI for this showdown with Taty Castellanos and Luis Alberto’s Lazio.
It kicks off at San Siro at 17.00 UK time (16.00 GMT).
The Rossoneri caught Inter on top of the table with a 3-1 win away to Cagliari and the absentee list is finally starting to come down.
Maignan returns in goal and Davide Calabria is available again too, while Leao and Giroud were rested midweek in Sardinia.
Ismael Bennacer, Rade Krunic, Pierre Kalulu and Mattia Caldara are still out of action, so Yacine Adli is again used as the midfield playmaker.
Lazio also got back on track after one point from two games, defeating Torino 2-0.
Alessio Romagnoli broke his nose during that match and faces his former teammates with a protective mask.
Nicoló Rovella impressed in his first start for the club and is confirmed in midfield, supporting Luis Alberto, Felipe Anderson and Mattia Zaccagni.
Taty Castellanos gets his first start, allowing Ciro Immobile rest ahead of the Champions League also due to a slight muscular issue.
Daichi Kamada had agreed terms with Milan over the summer, only for the club to change their minds after sacking Paolo Maldini, so he joined Lazio as a free agent instead.
Milan: Maignan; Calabria, Kjaer, Tomori, Theo Hernandez; Loftus-Cheek, Adli, Reijnders; Pulisic, Giroud, Leao
Lazio: Provedel; Marusic, Casale, Romagnoli, Hysaj; Guendouzi, Rovella, Luis Alberto; Felipe Anderson, Castellanos, Zaccagni
Player statistic
| 51' |  |
Adam Marusic | ||
| Christian Pulisic (Assist: Rafael Leão) |
 |
60' | ||
| 64' | |
Alessio Romagnoli | ||
| Rafael Leão | |
65' | ||
| Theo Hernández | |
84' | ||
| Mike Maignan | |
86' | ||
| Noah Okafor (Assist: Rafael Leão) |
|
88' |
Match statistic
