Milan are decimated with a makeshift defence including Theo Hernandez as centre-back as they host high-flying Frosinone, including Arijon Ibrahimovic.
It kicks off at San Siro at 19.45 GMT.
The injury crisis only intensified during the disastrous Champions League defeat to Borussia Dortmund when Malick Thiaw suffered a serious thigh strain.
He joins Rafael Leao, Pierre Kalulu, Simon Kjaer, Marco Pellegrino, Mattia Caldara, Noah Okafor and Marco Sportiello on the treatment table, while Olivier Giroud continues his two-match Serie A ban.
The situation is so bad that Theo Hernandez is used as a centre-back, the only alternative being 18-year-old youth team player Jan-Carlo Simic, Alessandro Florenzi starts at left-back.
Luka Jovic is the only striker in the squad other than 15-year-old Francesco Camarda.
The only positive is the return of Ismael Bennacer to the bench after six months out with a torn anterior cruciate ligament.
Frosinone are doing very well for a newly-promoted side, sitting in mid-table, but are also deeply unpredictable after a 4-3 defeat to Cagliari, a game they had been leading 3-0 at the 70th minute.
Soufiane Bidaoui, Pol Lirola, Riccardo Marchizza and Abdou Harroui are still out of action, while Luca Mazzitelli is not at 100 per cent either.
They start 17-year-old Arijon Ibrahimovic upfront – no relation to Zlatan – and Juventus-owned striker Matias Soule, Reinier on loan from Real Madrid and Morocco international Walid Cheddira.
Milan: Maignan; Calabria, Tomori, Hernandez, Florenzi; Loftus-Cheek, Reijnders, Musah; Chukwueze, Jovic, Pulisic
Frosinone: Turati; Monterisi, Okoli, Romagnoli, Oyono; Barrenechea, Bourabia; Soulé, Reinier, Ibrahimovic; Cuni
Player statistic
| Luka Jovic |  |
43' |
| Christian Pulisic (Assist: Mike Maignan) |
|
50' | ||
| 63' |  |
Enzo Barrenechea | ||
| Fikayo Tomori (Assist: Luka Jovic) |
|
74' | ||
| Luka Jovic | |
80' | ||
| 82' | |
Marco Brescianini |
Match statistic
