Milan finally have Mike Maignan back in goal after five months with Rafael Leao and Olivier Giroud upfront, while Atalanta look to Rasmus Hojlund and Ademola Lookman in this head-to-head for European places.
It kicks off at the Stadio Giuseppe Meazza, in the San Siro area of Milan, at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Rossoneri have regained their confidence after a disastrous start to 2023, stringing together three 1-0 wins between Serie A and the Champions League.
As Inter were beaten by Bologna earlier today, a win would allow Milan to catch their rivals in joint second place.
There is a further boost with the return of Maignan in goal for the first time since September 18, having finally made a full recovery from the calf strain he first sustained on international duty.
Ismael Bennacer, Davide Calabria and Alessandro Florenzi are still out of action, but Zlatan Ibrahimovic is also hoping to make his first appearance since knee surgery in May 2022.
The 3-4-2-1 formation is starting to settle, with Malick Thiaw in defence, Brahim Diaz and Rafael Leao supporting Giroud.
Atalanta are a deeply unpredictable side, in recent weeks able to beat Lazio and hold Juventus to a 3-3 draw, yet also lose to Sassuolo and Lecce.
Merih Demiral is suspended, with Hans Hateboer, Duvan Zapata and Mario Pasalic injured.
Marten de Roon and Giorgio Scalvini return from their bans, but all eyes are on the exciting strikers Rasmus Hojlund and Ademola Lookman.
La Dea have not beaten Milan since a 3-0 result here in January 2021, followed by three straight defeats and the 1-1 draw they played in Week 2.
The 5-0 humiliation in Bergamo in December 2019 sparked a tactical and personnel transformation for Stefano Pioli’s side that culminated in the Scudetto.
Milan: Maignan; Kalulu, Thiaw, Tomori; Messias, Tonali, Krunic, Theo Hernandez; Brahim Diaz, Giroud, Leao
Atalanta: Musso; Toloi, Djimsiti, Scalvini; Zappacosta, De Roon, Koopmeiners, Maehle; Lookman, Hojlund, Ederson
(Assist: Rafael Leão)