Roma need a win to recapture third place from Milan, so look to Paulo Dybala, Lorenzo Pellegrini and Tammy Abraham, but Lecce have caused upsets here and start Samuel Umtiti in defence.
It kicks off at the Stadio Via del Mare at 17.00 GMT.
Milan beat Torino 1-0 last night to temporarily go third, so Jose Mourinho’s men need a win to leapfrog them all over again, or at least a draw to go level.
Nicolò Zaniolo has been sold to Galatasaray and Rick Karsdorp is still frozen out, with Leonardo Spinazzola injured, but Georginio Wijnaldum is at least on the bench.
Lecce already beat Lazio here and held Milan to a 2-2 draw in 2023, so are not to be underestimated.
When they met in October, Roma barely scraped a 2-1 win despite Morten Hjulmand being sent off just 23 minutes in.
Youssef Maleh, Kastriot Dermaku and Marin Pongracic are out of action, with former Barcelona defender Umtiti marshalling the defence.
Strefezza and Colombo are joined by Federico Di Francesco, the son of ex-Roma coach Eusebio, in the trident attack.
Lecce: Falcone; Gendrey, Baschirotto, Umtiti, Gallo; Gonzalez, Hjulmand, Blin; Strefezza, Colombo, Di Francesco
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Zalewski, Cristante, Matic, El Shaarawy; Pellegrini, Dybala; Abraham
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