Roma are forced into changes for the trip to Lecce, so Tommaso Baldanzi and Nicola Zalewski support Romelu Lukaku.
It kicks off at the Stadio Via del Mare at 17.00 UK time (16.00 GMT).
Daniele De Rossi has transformed the Giallorossi since taking over from Jose Mourinho in mid-January and hopes to continue the push towards Champions League qualification.
However, captain Lorenzo Pellegrini is suspended, with Sardar Azmoun and Rasmus Kristensen injured, while Paulo Dybala and Leonardo Spinazzola are only fit for a spot on the bench.
Baldanzi therefore gets the nod with Zalewski in support of Lukaku, while Edoardo Bove is in midfield.
Lecce are missing Lameck Banda, Kastriot Dermaku, Mohamed Kaba and Jeppe Corfitzen, while Nicola Sansone had a stomach bug.
They were revitalised by new coach Luca Gotti, beating rock bottom Salernitana 1-0 to end their run of one win and two draws in 12 rounds.
Lecce: Falcone; Gendrey, Baschirotto, Pongracic, Gallo; Blin, Ramadani, Dorgu; Almqvist, Piccoli, Krstovic
Roma: Svilar; Karsdorp, Mancini, Ndicka, Angeliño; Cristante, Paredes, Bove; Baldanzi, Zalewski; Lukaku
Player statistic
| 11' |  |
Evan Ndicka | ||
| Roberto Piccoli | |
38' | ||
| Federico Baschirotto | |
45' |
| Ylber Ramadani | |
81' | ||
| 84' | |
Bryan Cristante |
Match statistic
