Juventus are decimated for their trip to Lecce, where only one team has won away this season, so look to Arkadiusz Milik with support from 19-year-old Matias Soulé.
It kicks off at the Stadio Via del Mare at 17.00 UK time (16.00 GMT).
The Old Lady are in a deep crisis and were eliminated from the Champions League after the 4-3 midweek defeat to Benfica, a game they had been trailing 4-1 before a late fightback.
To make matters worse, the absentee list now runs to 10 players, as Dusan Vlahovic and Manuel Locatelli haven’t made the trip either, joining Angel Di Maria, Leandro Paredes, Gleison Bremer, Mattia De Sciglio, Paul Pogba, Federico Chiesa, Kaio Jorge and Marley Ake in Turin.
Milik is therefore the centre-forward, so Federico Gatti, Fabio Miretti and 19-year-old striker Soulé step into the starting XI.
It is the first ever Serie A start for Argentina Under-20 international Soulé.
Lecce have only lost one home game this season, at the last second against Inter in the opening weekend, and also held Napoli to a 1-1 draw away, so are not to be under-estimated.
Antonino Gallo returns from suspension.
Lecce: Falcone; Gendrey, Pongracic, Baschirotto, Gallo; Blin, Hjulmand, Gonzalez; Strefezza, Ceesay, Oudin
Juventus: Szczesny; Cuadrado, Gatti, Danilo, Alex Sandro; McKennie, Miretti, Rabiot, Kostic; Soulé, Milik