Juventus have the chance to temporarily go top of the table and look towards Kenan Yildiz, Dusan Vlahovic and Weston McKennie for the trip to giant-killers Lecce.
It kicks off at the Stadio Via del Mare at 19.45 GMT.
This is a truncated weekend because Inter, Napoli, Fiorentina and Lazio are at the Supercoppa Italiana in Riyadh, so their Serie A fixtures are rescheduled.
It gives Juve the opportunity to take top spot in Inter’s absence, but while Weston McKennie and Federico Gatti return from suspension, they lose Federico Chiesa, Adrien Rabiot, Moise Kean and Mattia De Sciglio to injury.
Vlahovic is fired up after his brace against Sassuolo, again partnering impressive Turkish teenager Kenan Yildiz upfront.
Lecce have caused a few upsets already this season and are especially strong on home turf, where they beat Lazio and held Milan to a controversial 2-2 draw.
Their form has faltered lately with just one point from the last four rounds, during which they scored only one goal.
Lameck Banda, Hamza Rafia and Ahmed Touba are on international duty, with Kastriot Dermaku injured.
Lecce: Falcone; Gendrey, Pongracic, Baschirotto, Gallo; Kaba, Ramadani, Gonzalez; Oudin, Krstovic, Almqvist
Juventus: Szczesny; Gatti, Bremer, Danilo; Cambiaso, McKennie, Locatelli, Miretti, Kostic; Vlahovic, Yildiz
Player statistic
| 23' |  |
Weston McKennie |
| 60' |  |
Dusan Vlahovic (Assist: Andrea Cambiaso) | ||
| 68' | |
Dusan Vlahovic (Assist: Weston McKennie) | ||
| 85' | |
Bremer (Assist: Samuel Iling Junior) | ||
| Mohamed Kaba | |
89' |
Match statistic
