Maurizio Sarri is aiming for a second straight Serie A win with Ciro Immobile, Felipe Anderson and Pedro upfront against Thiago Motta’s Spezia.
It kicks off at the Stadio Olimpico at 17.30 UK time (16.30 GMT).
You can follow all the build-up and action as it happens from today’s four Serie A games on the LIVEBLOG.
The Aquile opened their campaign with a 3-1 comeback win over Empoli and have now sold Joaquin Correa to Inter, who made his debut with a brace last night against Verona.
Luis Alberto returns to the starting XI with Sergej Milinkovic-Savic, supporting Pedro, Immobile and Felipe Anderson.
Luiz Felipe is not 100 per cent fit, so Patric steps into the centre-back role.
Spezia fumbled a 2-0 lead for their 2-2 draw away to Cagliari under new coach Thiago Motta and are hoping for better this time around.
Leo Sena, Arkadiusz Reca and M’Bala Nzola are still out of action, so Emmanuel Gyasi is again flanked by Daniele Verde and Ebrima Colley.
New signing Janis Antiste is on the bench with Samuel Mraz.
Lazio: Reina; Lazzari, Patric, Acerbi, Hysaj; Milinkovic-Savic, Leiva, Luis Alberto; Pedro, Immobile, Felipe Anderson
Spezia: Zoet; Nikolaou, Erlic, Amian; S Bastoni, Maggiore, Ferrer, Vignali; Verde, Gyasi, Colley