Lazio are still missing Ciro Immobile, so look to Felipe Anderson as their False 9, while Salernitana start Krzysztof Piatek and Federico Bonazzoli.
It kicks off at the Stadio Olimpico at 17.00 GMT.
This is something of a curious derby, because until the final minute of December 31, both these clubs were owned by Claudio Lotito, which is against the rules in the same division.
He was forced to sell when Salernitana gained promotion last season, leaving it to the very last minute for the sale to Danilo Iervolino, after which Davide Nicola and new players were brought in for an amazing comeback to secure safety.
Lazio have kept six consecutive Serie A clean sheets and won in the Europa League midweek, but are without top scorer Immobile due to injury.
Felipe Anderson is again picked as the False 9, flanked by Pedro and Mattia Zaccagni.
Sergej Milinkovic-Savic is on a yellow card, so at risk of missing next week’s Rome Derby with a booking and is therefore rested.
Salernitana make the trip without Giulio Maggiore, while Boulaye Dia is not 100 per cent fit, so Piatek and Bonazzoli lead the attack with support from ex-Lazio star Antonio Candreva.
Lazio: Provedel; Lazzari, Casale, Romagnoli, Marusic; Vecino, Cataldi, Luis Alberto; Pedro, Felipe Anderson, Zaccagni
Salernitana: Sepe; Gyomber, Daniliuc, Fazio; Candreva, Radovanovic, Coulibaly, Bradaric, Mazzocchi; Bonazzoli, Piatek