Lazio try to shake off their derby disappointment and focus on European qualification, but have serious injury problems against Salernitana.
It kicks off at the Stadio Olimpico at 19.45 UK time (18.45 GMT).
The Aquile are still shaken after their Derby della Capitale defeat to arch-rivals Roma, which followed a loss in the first leg of the Coppa Italia semi-final to Juventus.
New coach Igor Tudor has been thrown right in at the deep end, making his debut with back-to-back Juve games and Roma, so this will feel like a chance to get points on the board against rock bottom Salernitana.
He has a decimated squad, missing Ciro Immobile, Mattia Zaccagni, Ivan Provedel, Matteo Guendouzi, Alessio Romagnoli and Luca Pellegrini.
Luis Alberto is therefore in a more advanced role with Felipe Anderson supporting Taty Castellanos, with Daichi Kamada in midfield.
Salernitana are practically doomed to the drop already under fourth coach of the campaign Stefano Colantuono and make the trip without Grigoris Kastanos and Lazio-owned Toma Basic.
Boulaye Dia is also still frozen out after his refusal to come on as a substitute last month.
Former Lazio man Antonio Candreva visits his old hunting ground.
Lazio: Mandas; Patric, Casale, Gila; Marusic, Vecino, Kamada, Lazzari; Felipe Anderson, Luis Alberto; Castellanos
Salernitana: Costil; Gyomber, Boateng, Pirola, Bradaric; Zanoli, Coulibaly, Maggiore, Tchaouna; Candreva; Ikwuemesi
Player statistic
| Felipe Anderson |  |
7' | ||
| Matías Vecino | |
14' | ||
| 16' | |
Loum Tchaouna (Assist: Giulio Maggiore) | ||
| Felipe Anderson (Assist: Luis Alberto) |
|
35' | ||
| 36' |  |
Lassana Coulibaly |
| Gustav Isaksen (Assist: Nicolò Rovella) |
|
87' |
Match statistic
