It is not just a Derby della Capitale, but also a showdown for the top four, as Roma look to Paulo Dybala and Andrea Belotti, while Lazio are again without Ciro Immobile and take a risk with Ivan Provedel.
It kicks off at the Stadio Olimpico at 17.00 GMT.
Both teams were involved in Europe on Thursday, but with very different results, as while Roma held off Real Sociedad to set up a Europa League quarter-final with Feyenoord, Lazio were eliminated from the Conference League by AZ Alkmaar.
There is so much at stake here, as a win would let Roma leapfrog Milan and Lazio into third place, while a victory for the Aquile would create a buffer zone for the Champions League spots.
Immobile is injured again, having also missed the first derby this season that was won by Lazio, so Felipe Anderson is the False 9 flanked by Pedro and Mattia Zaccagni.
Matias Vecino is suspended, replaced by Danilo Cataldi.
There was also a late blow for Maurizio Sarri, because goalkeeper Provedel woke up with flu symptoms, but is pushing through the pain to start rather than Luis Maximiano.
Despite being signed for €10m over the summer, the Portuguese shot-stopper made only one Serie A appearance, which saw him sent off after six minutes for handling outside the box.
Roma do not have coach Jose Mourinho on the bench due to a controversial two-match touchline ban after his row with fourth official Marco Serra.
Marash Kumbulla is suspended too following his reaction foul in the 4-3 defeat to Sassuolo, while Rick Karsdorp had surgery yesterday after breaking his nose against Real Sociedad.
Bryan Cristante returns from his ban, while Nemanja Matic is out again after a stomach bug saw him miss the Europa League tie.
Belotti is preferred to Tammy Abraham.
Lazio: Provedel; Marusic, Casale, Romagnoli, Hysaj; Milinkovic-Savic, Cataldi, Luis Alberto; Pedro, Felipe Anderson, Zaccagni
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Zalewski, Cristante, Wijnaldum, Spinazzola; Dybala, Pellegrini; Belotti
Player statistic
| 8' |  |
Roger Ibañez | ||
| Luis Alberto | |
26' | ||
| 32' |  |
Roger Ibañez |
| Alessio Romagnoli | |
60' | ||
| Mattia Zaccagni (Assist: Felipe Anderson) |
 |
65' | ||
| 71' | |
Bryan Cristante | ||
| 80' | |
Gianluca Mancini | ||
| Matteo Cancellieri | |
89' | ||
| Toma Basic | |
90+2' | ||
| Adam Marusic |  |
90+7' | ||
| 90+7' | |
Bryan Cristante |
Match statistic
