Milan need the victory to stay top of the table with Brahim Diaz, Rafael Leao and Olivier Giroud against Ciro Immobile and Sergej Milinkovic-Savic’s Lazio.
It kicks off at the Stadio Olimpico at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
Serie A Liveblog: Inc Lazio-Milan, Empoli-Napoli, Salernitana-Fiorentina
Inter beat Roma 3-1 yesterday, so technically they are the leaders, also having a game in hand to play against Bologna on Wednesday.
These sides met twice already this season, Milan winning 2-0 in Serie A and 4-0 in the Coppa Italia, both at San Siro.
It will feel like a home match, because the Lazio ultras are on strike in protest over high ticket prices, so circa 10,000 Rossoneri supporters are crowding into the Stadio Olimpico.
Ismael Bennacer joined Alessandro Florenzi and Simon Kjaer on the treatment table, with Alessio Romagnoli – widely expected to join Lazio as a free agent – back on the bench after his injury.
Zlatan Ibrahimovic and Ante Rebic are also in the squad, but not ready to start, so Brahim Diaz, Junior Messias and Rafael Leao fan out behind Giroud.
Lazio were struck by a flu outbreak at the training ground this week, with eight players out of action simultaneously, but they have almost all recovered.
Only Adam Marusic is still unwell, with Pedro injured, and goalkeeper Thomas Strakosha was the biggest doubt until the final moment, but both he and Patric start.
It’s Felipe Anderson, Immobile and Mattia Zaccagni upfront again.
Lazio: Strakosha; Lazzari, Acerbi, Patric, Radu; Milinkovic-Savic, Leiva, Luis Alberto; Felipe Anderson, Immobile, Zaccagni
Milan: Maignan; Calabria, Kalulu, Tomori, Theo Hernandez; Tonali, Kessie; Messias, Brahim Diaz, Leao; Giroud