Olivier Giroud, Rafael Leao and Ruben Loftus-Cheek lead the way for Milan against Taty Castellanos, Luis Alberto and Mattia Zaccagni’s Lazio.
It kicks off at the Stadio Olimpico at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
This is the opening fixture for Serie A Week 27 and is played on Friday so that Lazio can prepare for the Champions League trip to Bayern Munich on Tuesday.
Patric and Nicolò Rovella are still not fully fit, but Mario Gila returns in central defence with Alessio Romagnoli against his former club.
Castellanos gets the nod upfront ahead of Ciro Immobile, while Zaccagni is back in the starting XI after a muscular injury.
Milan are still missing suspended Luka Jovic and injured Tommaso Pobega, but Pierre Kalulu and Fikayo Tomori are on the bench after long lay-offs.
Theo Hernandez sustained a knock during the 1-1 draw with Atalanta and the Rossoneri have managed just one point from their last three competitive games.
Tijjani Reijnders is rested, having just become a father.
Lazio: Provedel; Marusic, Gila, Romagnoli, Pellegrini; Guendouzi, Vecino, Luis Alberto; Felipe Anderson, Castellanos, Zaccagni
Milan: Maignan; Florenzi, Kjaer, Gabbia, Theo Hernandez; Bennacer, Adli; Pulisic, Loftus-Cheek, Leao; Giroud
Player statistic
| Luca Pellegrini |  |
50' | ||
| Luca Pellegrini |  |
57' | ||
| Alessio Romagnoli | |
58' | ||
| 61' | |
Alessandro Florenzi | ||
| 70' | |
Yacine Adli | ||
| Ciro Immobile | |
78' | ||
| 80' | |
Matteo Gabbia | ||
| 84' | |
Theo Hernández | ||
| 88' |  |
Noah Okafor | ||
| Elseid Hysaj | |
90' | ||
| Adam Marusic |  |
90+5' | ||
| Mattéo Guendouzi | |
90+6' | ||
| 90+5' | |
Rafael Leão | ||
| 90+6' | |
Christian Pulisic |
Match statistic
