Igor Tudor makes his debut as Lazio coach with Taty Castellanos and a new system, while Max Allegri revamps Juventus with Federico Chiesa and Moise Kean in a 4-3-3.
It kicks off at the Stadio Olimpico at 17.00 GMT.
The last few weeks have been troubled for both clubs, who will meet again in the Coppa Italia semi-final on April 2 and 23.
The Biancocelesti are still reeling after Maurizio Sarri’s sudden resignation and his assistant manager Giovanni Martusciello was on the bench for the win over Frosinone.
Tudor, a former Juventus defender and assistant manager under Andrea Pirlo, took over during the break for international duty.
He wasted no time, transforming Sarri’s classic 4-3-3 to a 3-4-2-1 with Pedro and Mattia Zaccagni behind Castellanos.
Luis Alberto is not fully fit, but Daichi Kamada is preferred to Matteo Guendouzi in midfield.
Ivan Provedel is still out with a sprained ankle, plus Manuel Lazzari, Nicolò Rovella and suspended Luca Pellegrini.
Juventus have been struggling lately too and Dusan Vlahovic was sent off in the draw with Genoa, so he sits out a ban with injured Arkadiusz Milik, Filip Kostic, Alex Sandro and Carlos Alcaraz.
On his 500th Serie A match, Allegri finally bows to pressure and changes the 3-5-2 formation to 4-3-3 with Kean as centre-forward, flanked by Chiesa and Andrea Cambiaso.
Mattia De Sciglio returns to the starting XI after an 11-month absence.
Lazio: Mandas; Gila, Romagnoli, Casale; Marusic, Cataldi, Kamada, Felipe Anderson; Pedro, Zaccagni; Castellanos
Juventus: Szczesny; Danilo, Bremer, Rugani, De Sciglio; Miretti, Locatelli, Rabiot, Cambiaso, Kean, Chiesa
Player statistic
| 71' |  |
Samuel Iling-Junior | ||
| 75' | |
Timothy Weah | ||
| Ciro Immobile | |
90+1' | ||
| Adam Marusic (Assist: Mattéo Guendouzi) |
 |
90+3' |
Match statistic
Kean instead of Yildiz????? Allegri OUT