Juventus pull a surprise by debuting Enzo Barrenechea with Angel Di Maria and Dusan Vlahovic, while Torino hope Antonio Sanabria can win their first Derby della Mole in nearly eight years.
It kicks off at the Allianz Juventus Stadium in Turin at 19.45 GMT.
The Bianconeri go into this clash brimming with confidence after three straight Serie A wins, plus a dominant Europa League play-off victory away to FC Nantes on Thursday, decided by Di Maria’s hat-trick.
The World Cup winner leads the way again, this time with Vlahovic, but Arkadiusz Milk, Fabio Miretti and suspended Manuel Locatelli miss out.
Instead of Leandro Paredes, Max Allegri opts to start 21-year-old youth team product Barrenechea on his Serie A debut, having played just a few minutes as a substitute in the Champions League.
Federico Chiesa and Paul Pogba are both on the bench and could potentially make an appearance.
Torino have Ola Aina sitting out a ban, with Nikola Vlasic, David Zima, Pietro Pellegri, Ronaldo Vieira and Valentino Lazaro injured.
Ivan Ilic has shaken off a muscular issue to start, but Simone Ricci is only fit enough for a spot on the bench.
Aleksei Miranchuk and Yann Karamoh supports Tonny Sanabria upfront.
The Granata ultras are boycotting this match in protest at having to register with the Juventus website to buy tickets.
Toro have not won the Derby della Mole since a 2-1 home result in April 2015, scraping four draws and 13 losses including the Coppa Italia, while the most recent ‘away’ victory was 2-1 in April 1995.
Juventus: Szczesny; Danilo, Bremer, Alex Sandro; Cuadrado, Fagioli, Barrenechea, Rabiot, Kostic; Di Maria; Vlahovic
Torino: Milinkovic-Savic; Djidji, Schuurs, Buongiorno; Singo, Linetty, Ilic, Rodriguez; Miranchuk, Karamoh; Sanabria
Player statistic
| 2' |  |
Yann Karamoh (Assist: Alessandro Buongiorno) | ||
| Juan Cuadrado (Assist: Filip Kostic) |
|
16' | ||
| 43' | |
Antonio Sanabria (Assist: Ivan Ilić) | ||
| Danilo (Assist: Ángel Di María) |
|
45+2' |
| 60' |  |
Ricardo Rodríguez | ||
| Bremer (Assist: Federico Chiesa) |
|
71' | ||
| Adrien Rabiot (Assist: Bremer) |
|
81' | ||
| 90+5' | |
Samuele Ricci |
Match statistic
