Juventus make radical changes to get back on track against Spezia, starting Moise Kean, Fabio Miretti and Federico Gatti amid an injury crisis.
It kicks off at the Allianz Juventus Stadium at 19.45 UK time (18.45 GMT).
The Bianconeri are coming off back-to-back stalemates with Sampdoria and Roma, coach Max Allegri dealing with injuries to Leonardo Bonucci, Paul Pogba, Federico Chiesa and Kaio Jorge.
Arthur Melo is still frozen out pending a transfer, while Angel Di Maria is back on the bench after his muscular strain.
Max Allegri gives youth a go with Gatti getting his Serie A debut in defence, Miretti in midfield and Kean joining Dusan Vlahovic upfront.
Spezia were hammered 3-0 by Inter, but recovered for a 2-2 draw with Sassuolo at the weekend.
Albin Ekdal sits out a ban with Daniel Maldini, Kelvin Amian and Salva Ferrer carrying injuries.
Juventus: Szczesny; Danilo, Bremer, Gatti, De Sciglio; Locatelli, Miretti, Rabiot; Cuadrado, Vlahovic, Kean
Spezia: Dragowski; Hristov, Kiwior, Nikolaou; Gyasi, Holm, Kovalenko, Bourabia, Bastoni, Reca; Nzola
Why start Cuadrado?